Polydatin (PD), a natural precursor of resveratrol, has a variety of biological activities,
including anti‑tumor effects. However, the underlying molecular mechanisms of the anti-cancer
activity of PD has not been fully elucidated. The present study demonstrated that PD significantly
inhibited the proliferation of the MOLT-4 leukemia cell line in a dose‑ and time-dependent manner by
using Cell Counting Kit‑8 assay…
Polydatin (PD), a small natural compound from Polygonum cuspidatum, has a number of biological
functions. However, the anticancer activity of PD has been poorly investigated. In the present
thiazolyl blue tetrazolium bromide assay was used to evaluate the inhibitory effect of PD on cell
growth. Cell cycle distribution and apoptosis were investigated by flow cytometry…
Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T
recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to
involved in a number of chronic disorders although the mechanisms regulating its production in
inflammatory disease are still unclear. The beneficial properties of the polyphenolic compound
resveratrol including its anti-inflammatory, antioxidant, and antitumor effects, its role in the
process and in the prevention of heart and neurodegenerative diseases are well-known….
Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions,
anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC)
have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay,
wound healing assay were performed to determine cell proliferation, invasion and migration. Flow
cytometry and TUNEL assay were used to measure cell apoptosis….
This study was designed to investigate the effects of polydatin in the progression of NSCLC. CCK-8
assay, wound healing assay and western blot assay were used to assess the anti-cancer property.
Consequently, we showed that polydatin inhibited proliferation and migration of NSCLC cells (A549
H1299 cells) in a dose-dependent manner. In addition, polydatin suppressed the expression of NLRP3,
and pro-caspase-1in NSCLC cells….
Polydatin, extracted from Polygonum cuspidatum, is known for its anti‑platelet aggregation and
anti‑inflammatory effects. However, studies on the association of polydatin with cancer are limited,
particularly with regards to epithelial‑mesenchymal transition (EMT)‑associated migration and
of cancer cells. The purpose of the present study was to reveal the potential anticancer effects of
polydatin on hepatocellular carcinoma (HCC) cells, particularly its effects on EMT….
Polydatin effectively inhibited cell proliferation and promoted cell apoptosis in CRC cell lines.
was confirmed as a direct target of miR-382. Furthermore, Polydatin could suppress the expression of
PD-L1 by upregulating miR-382. Moreover, Polydatin inhibits proliferation and promotes apoptosis of
cells by regulating miR-382 and suppressing CRC tumor growth in vivo….
Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and
therefore, finding an effective treatment is of the utmost importance. Resveratrol, which exhibits
neuroprotective effects, has low bioavailability. However, it’s glucoside polydatin is more
bioavailable. Here, the evidence that supports the protective role of polydatin against
dementia-related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia,
Lewy body dementias is presented….
Oxidative stress-mediated proliferation of vascular smooth muscle cells (VSMCs) contributes to
formation and the progression of atherosclerosis. Polydatin is a derivative of resveratrol, and is
widely present in certain herbal medications used for the treatment of cardiovascular diseases. In
present study, we examined whether polydatin was capable of attenuating VSMC proliferation induced
oxidative stress as well as the potential involvement of the endothelial nitric oxide synthetase
Background Abnormalities in lipid and glucose metabolism are constantly observed in type 2 diabetes.
However, these abnormalities can be ameliorated by polydatin. Considering the important role of
proprotein convertase subtilisin/kexin type 9 (PCSK9) in metabolic diseases, we explore the possible
mechanism of polydatin on lipid and glucose metabolism through its effects on PCSK9. Methods An
insulin-resistant HepG2 cell model induced by palmitic acid (PA) and a db/db mice model were used to
clarify the role of polydatin on lipid and glucose metabolism….
Recently, the effect of polydatin on lipid regulation has gained considerable attention. And
study has demonstrated that polydatin has hypoglycemic effect on experimental diabetic rats.
Akt pathway contributes to glucose and lipid disorders in diabetes. Thus, whether polydatin
glucose and lipid metabolism in experimental diabetic models through the Akt pathway arouses
The purpose was to explore the regulatory mechanism of polydain on glucose and lipid through Akt
Polydatin, an active ingredient isolated from the natural medicine Polygonum cuspidatum, has
to have a prominent role in the treatment of cardiovascular diseases. Polydatin treats
mainly from three aspects: anti-inflammatory, regulating lipid metabolism and anti-oxidative stress.
This article will review the pharmacological mechanism of polydatin in anti-atherosclerosis, the
biological characteristics of Polygonum cuspidatum, the toxicology and pharmacokinetics of polydatin
and will provide ideas for further research….